Journal article

Aspartate 313 in the Streptomyces plicatus hexosaminidase plays a critical role in substrate-assisted catalysis by orienting the 2-acetamido group and stabilizing the transition state

SJ Williams, BL Mark, DJ Vocadlo, MNG James, SG Withers

Journal of Biological Chemistry | AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC | Published : 2002

DOI: 10.1074/jbc.M206481200

University of Melbourne Researchers

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Keywords

Crystal-Structure
Mechanism
Biochemistry & Molecular Biology
Azides
Life Sciences & Biomedicine
Identification
Stereochemistry
Hyaluronoglucosaminidase
Sequence-Based Classification
Beta-N-Acetylhexosaminidases
Protein Binding
Protein Structure, Tertiary
Glycosyl Hydrolases
Oxazoles
Catalysis
Aspartic Acid
Streptomyces
Hydrogen-Ion Concentration
Protein Conformation
Sequence Homology, Amino Acid
Amino Acid Sequence
Dose-Response Relationship, Drug
Kinetics
Science & Technology
Mutagenesis, Site-Directed
Models, Molecular
Beta-N-Acetylhexosaminidase
Site
Models, Chemical
Molecular Sequence Data
Ions
Chitobiase
Chitinase
Electrons