Anomeric Anhydro Sugars

Abstract

Anomeric anhydro sugars are an important class of sugar derivatives in which the anomeric carbon participates in an acetal linkage with two of the hydroxy groups of the sugar [1], Such anhydro sugars are, therefore, essentially internal glycosides which may be formally derived from the cyclic parent sugar by the loss of a molecule of water. More importantly, this internal acetalization of the anomeric center serves to protect the position and allows for selective reactions to be performed on the remaining hydroxy groups. In addition, anomeric anhydro sugars are frequently restricted to a limited conformational space which further influences the reactivity of the remaining hydroxy groups. Man..