An open-label study of quetiapine in anorexia nervosa

Abstract

Background: Atypical antipsychotics may be beneficial in treating the core psychopathology of anorexia nervosa (AN). Methods: An 8 week open-label study of quetiapine was conducted in eight severely ill DSM-IVAN patients consecutively admitted to a specialist eating disorders unit. Participants were assessed by EDE-12, MADRS, YBOCS, SAPS-delusions and CDR neuropsychological battery at baseline, 4 weeks and 8 weeks, and by weekly body mass index (BMI), CGI and extrapyramidal scores. Quetiapine doses ranged from 50mg to 800mg per day, according to efficacy and tolerability. Results: Seven participants completed 4 weeks and five participants completed 8 weeks. All participants had clinically si..