Journal article

Cell proliferation drives neural crest cell invasion of the intestine

Matthew J Simpson, Dong C Zhang, Michael Mariani, Kerry A Landman, Donald F Newgreen

DEVELOPMENTAL BIOLOGY | ACADEMIC PRESS INC ELSEVIER SCIENCE | Published : 2007

Abstract

A general mathematical model of cell invasion is developed and validated with an experimental system. The model incorporates two basic cell functions: non-directed (diffusive) motility and proliferation to a carrying capacity limit. The model is used here to investigate cell proliferation and motility differences along the axis of an invasion wave. Mathematical simulations yield surprising and counterintuitive predictions. In this general scenario, cells at the invasive front are proliferative and migrate into previously unoccupied tissues while those behind the front are essentially nonproliferative and do not directly migrate into unoccupied tissues. These differences are not innate to the..

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University of Melbourne Researchers