History of depression as a risk factor for dementia: An updated review

Abstract

Objective: This review updates an earlier meta-analysis of the data on history of depression as a risk factor for dementia. It also considers the available evidence on the hypotheses proposed to explain the association between history of depression and dementia. Method: A meta-analysis was carried out on results from seven case-control and six prospective studies. A qualitative review was carried out on the evidence related to the hypotheses to explain the association. Results: The meta-analysis found evidence to support an association from both case-control studies (estimated relative risk 2.01; 95% Cl 1.16-3.50) and prospective studies (estimated relative risk 1.87; 95% Cl 1.09-3.20). Howe..