Journal article

The fur seal - a model lactation phenotype to explore molecular factors involved in the initiation of apoptosis at involution

Julie A Sharp, Christophe Lefevre, Amelia J Brennan, Kevin R Nicholas

Journal of Mammary Gland Biology and Neoplasia | SPRINGER/PLENUM PUBLISHERS | Published : 2007


Mammary gland involution requires co-ordination of milk production, immune responses, apoptosis and remodeling. Initiation and progression of each of these components involves integral control by the mammary gland. Although cell-based culture models and genetically manipulated animals have shed light on these processes, the factors controlling each step in the involution cascade are still poorly understood. The fur seal displays a unique lactation phenotype. During the lactation cycle the mammary gland downregulates milk production and initiates an immune response but fails to initiate the apoptotic phase of involution, allowing the female fur seal to undertake long foraging trips of up to 2..

View full abstract