Journal article
Multifunctional nanoparticle platforms for in vivo MRI enhancement and photodynamic therapy of a rat brain cancer
R Kopelman, YE Lee Koo, M Philbert, BA Moffat, G Ramachandra Reddy, P McConville, DE Hall, TL Chenevert, MS Bhojani, SM Buck, A Rehemtulla, BD Ross
Journal of Magnetism and Magnetic Materials | Published : 2005
Abstract
A paradigm for brain cancer detection, treatment, and monitoring is established. Multifunctional biomedical nanoparticles (30-60 nm) containing photosensitizer externally deliver reactive oxygen species (ROS) to cancer cells while simultaneously enhancing magnetic resonance imaging (MRI) contrast providing real-time tumor kill measurement. Plasma residence time control and specific cell targeting are achieved. A 5 min treatment in rats halted and even reversed in vivo tumor growth after 3-4 days post-treatment. © 2005 Elsevier B.V. All rights reserved.