Journal article

Requirements for autoimmune responses to mouse gastric autoantigens

KL Scarff, LM Judd, WE Wilson, KL Laurie, BH Toh, PA Gleeson, IR van Driel

IMMUNOLOGY | BLACKWELL SCIENCE LTD | Published : 2001

Abstract

Autoimmune gastritis, in which the H+/K(+)-ATPase of parietal cells is the major antigen, is one of the most common autoimmune diseases. Here we examined if specific properties of the H+/K(+)-ATPase or parietal cells are involved in rendering them autoimmune targets. The model antigens beta-galactosidase and ovalbumin (OVA) were expressed in parietal cells of transgenic mice. On experimental induction of autoimmune gastritis by neonatal thymectomy, autoantibodies to beta-galactosidase developed in mice expressing beta-galactosidase in parietal cells, a response that was independent of either the response to the gastric H+/K(+)-ATPase or gastric inflammation. In contrast, mice that expressed ..

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