Journal article

Association between the COMT Val(158)Met polymorphism and propensity to anxiety in an Australian population-based longitudinal study of adolescent health

CA Olsson, RJL Anney, M Lotfi-Miri, GB Byrnes, R Williamson, GC Patton

PSYCHIATRIC GENETICS | LIPPINCOTT WILLIAMS & WILKINS | Published : 2005

Abstract

OBJECTIVES: Catechol-O-methyltransferase plays a central role in the metabolism of biogenic amines such as norepinephrine, dopamine and serotonin. Functional studies have demonstrated a dose relationship between ValMet genotypes and catechol-O-methyltransferase activity. Compared with the ValVal genotype, the ValMet and MetMet genotypes result in two- and four-fold reductions in catechol-O-methyltransferase activity, respectively. Two recent reports have observed the association between the MetMet genotype and risk of anxiety in adult populations. We examined the association between the ValMet genotypes and propensity to anxiety across adolescence. METHODS: Participants were drawn from an ei..

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