Journal article

Inhibition of vascular endothelial growth factor (VEGF)-A causes a paradoxical increase in tumor blood flow and up-regulation of VEGF-D

BA Moffat, M Chen, MST Kariaapper, DA Hamstra, DE Hall, J Stojanovska, TD Johnson, M Blaivas, M Kumar, TL Chenevert, A Rehemtulla, BD Ross

CLINICAL CANCER RESEARCH | AMER ASSOC CANCER RESEARCH | Published : 2006

Abstract

PURPOSE: Vascular endothelial growth factor (VEGF)-A is an important mediator of angiogenesis in almost all solid tumors. The aim of this study was to evaluate the effect of VEGF-A expression on tumor growth, perfusion, and chemotherapeutic efficacy in orthotopic 9L gliosarcomas. EXPERIMENTAL DESIGN: Stable 9L cell lines underexpressing and overexpressing VEGF-A were generated. Anatomic, susceptibility contrast, and continuous arterial spin-labeling magnetic resonance imaging were used to quantify the volume, blood volume, and blood flow of tumors orthotopically grown from these and wild-type 9L cells. Histologic, immunohistochemical, and quantitative reverse transcription-PCR analyses were ..

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University of Melbourne Researchers