Journal article

Sequencing and mapping hemoglobin gene clusters in the Australian model dasyurid marsupial Sminthopsis macroura

AA De Leo, D Wheeler, C Lefevre, JF Cheng, R Hope, J Kuliwaba, KR Nicholas, M Westerman, JAM Graves

CYTOGENETIC AND GENOME RESEARCH | KARGER | Published : 2005

Abstract

Comparing globin genes and their flanking sequences across many species has allowed globin gene evolution to be reconstructed in great detail. Marsupial globin sequences have proved to be of exceptional significance. A previous finding of a beta(beta)-like omega(omega) gene in the alpha(alpha) cluster in the tammar wallaby suggested that the alpha and beta cluster evolved via genome duplication and loss rather than tandem duplication. To confirm and extend this important finding we isolated and sequenced BACs containing the alpha and beta loci from the distantly related Australian marsupial Sminthopsis macroura. We report that the alpha gene lies in the same BAC as the beta-like omega gene, ..

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University of Melbourne Researchers