Diffusion MRI: a new strategy for assessment of cancer therapeutic efficacy.
Thomas L Chenevert, Charles R Meyer, Bradford A Moffat, Alnawaz Rehemtulla, Suresh K Mukherji, Stephen S Gebarski, Douglas J Quint, Patricia L Robertson, Theodore S Lawrence, Larry Junck, Jeremy M Taylor, Timothy D Johnson, Qian Dong, Karin M Muraszko, James A Brunberg, Brian D Ross
Mol Imaging | Published : 2002
The use of anatomical imaging in clinical oncology practice traditionally relies on comparison of patient scans acquired before and following completion of therapeutic intervention. Therapeutic success is typically determined from inspection of gross anatomical images to assess changes in tumor size. Imaging could provide significant additional insight into therapeutic impact if a specific parameter or combination of parameters could be identified which reflect tissue changes at the cellular or physiologic level. This would provide an early indicator or treatment response/outcome in an individual patient before completion of therapy. Moreover, response of a tumor to therapeutic intervention ..View full abstract