Journal article

Subcutaneous administration of a recombinant vaccinia virus vaccine expressing multiple envelopes of HIV-1

KS Slobod, TD Lockey, N Howlett, RV Srinivas, SD Rencher, PJ Freiden, PC Doherty, JL Hurwitz

European Journal of Clinical Microbiology & Infectious Diseases | SPRINGER | Published : 2004

Abstract

A critical goal of HIV vaccine development is the identification of safe and immunogenic vectors. Recombinant vaccinia virus is a highly effective vaccine vector, with demonstrated capacity to protect animals from various viral pathogens, including rabies. Unlike many other candidate vaccine vectors, vast human experience exists with the parenteral smallpox vaccine. However, consideration of recombinant vaccinia virus as a modern vaccine is complicated by the relatively high prevalence of immunocompromised persons compared to such prevalence 4 or more decades ago (when smallpox vaccination was still routine). Administering vaccine by the subcutaneous (SQ) route, rather than the traditional s..

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University of Melbourne Researchers