Journal article

Generalized epilepsy with febrile seizures plus-associated sodium channel beta 1 subunit mutations severely reduce beta subunit-mediated modulation of sodium channel function

R Xu, EA Thomas, EV Gazina, KL Richards, M Quick, RH Wallace, LA Harkin, SE Heron, SF Berkovic, IE Scheffer, JC Mulley, S Petrou

Neuroscience | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2007

DOI: 10.1016/j.neuroscience.2007.05.038

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Keywords

Mutation
Temporal-Lobe Epilepsy
Molecular Determinants
Sodium Channels
Ion Channel Gating
Phenotypes
Genetic Predisposition To Disease
Absence Epilepsy
Neurosciences & Neurology
Synapses
Electrophysiology
Beta Subunit
Gene Scn1b
Expression
Genetics
Life Sciences & Biomedicine
Action Potentials
Cell Line
Brain Chemistry
Seizures, Febrile
Membrane Potentials
Patch-Clamp Techniques
Humans
Gefs
Beta-1-Subunit
Epilepsy, Generalized
Voltage-Gated Sodium Channel Beta-1 Subunit
Epilepsy
Dysfunction
Transfection
Neurosciences
Synaptic Transmission
Inactivation
Brain
Nerve Tissue Proteins
Nav1.1 Voltage-Gated Sodium Channel
Auxiliary
Science & Technology
Protein Subunits