Journal article

A genomewide linkage study of 1,933 families affected by premature coronary artery disease: The British heart foundation (BHF) family heart study

NJ Samani, P Burton, M Mangino, SG Ball, AJ Balmforth, J Barrett, T Bishop, A Hall, NJ Samani, J Stribling, P de Souza, R Singh, J Ogleby, C Ridge, E Logtens, L Hopwood, J Faulkes, AS Hall, C Morrell, BM Jackson Show all

AMERICAN JOURNAL OF HUMAN GENETICS | CELL PRESS | Published : 2005

Abstract

Coronary artery disease (CAD) and its most important complication, myocardial infarction (MI), are the leading cause of premature death in the Western world. CAD has a substantial genetic basis, especially when it occurs early. We investigated the genetic determinants of premature CAD by performing a genomewide linkage analysis of 4,175 affected subjects from 1,933 families recruited throughout the United Kingdom. Each family had at least two available siblings with CAD, with validated onset before age 66 years. Linkage analysis was performed using 416 microsatellite markers. We observed suggestive linkage, for both CAD and MI, to a region on chromosome 2. For CAD, a LOD score of 1.86 was ob..

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