Differential effect of CD8 and CD8- dendritic cells in the stimulation of secondary CD4 T cells

Abstract

Dendritic cells (DC), in their role in initiation of the adaptive immune response, have been extensively studied for their capacity to interact and stimulate naive T cells. Subsets of mature murine DC isolated directly from the spleen have been shown to differ in their ability to induce proliferative responses in both primary CD4+ and primary Cd8+ T cells; the myeloid-related CD8α- DC induce a more intense or prolonged proliferation of naive T cells than do the lymphoid-related DC bearing CD8α despite similar expression of MHC and co-stimulatory molecules. Here we examine the interaction of these DC subpopulations with T cells already in the activated or memory state which are known to have ..