Journal article

Lack of glutathione peroxidase-1 exacerbates A beta-mediated neurotoxicity in cortical neurons

PJ Crack, K Cimdins, U Ali, PJ Hertzog, RC Iannello

JOURNAL OF NEURAL TRANSMISSION | SPRINGER WIEN | Published : 2006

Abstract

The aetiologies of Alzheimer's disease (AD) are complex and multifactorial. Current therapies are largely ineffective, as the pathophysiological pathways are poorly understood. Observations in AD autopsies, as well as in vivo and in vitro observations in transgenic mice, have implicated oxidative stress as pathogenic in AD. This study used the Glutathione Peroxidase-1 knockout mouse (Gpx1--/--) model to investigate the role of antioxidant disparity in neuropathologies. Cultured neurons from control and Gpx1--/-- embryos were treated with AD-related peptides and the degree of cell loss compared. Results show that antioxidant disparity makes Gpx1--/-- cells more susceptible to Abeta toxicity. ..

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