Homocysteine and the brain in midadult life: Evidence for an increased risk of leukoaraiosis in men

Abstract

Background: High serum homocysteine (HCY) levels have been associated with thromboembolic cerebrovascular disease, but their relationship to microvascular disease is uncertain. Homocysteine also has a direct neurotoxic effect and has been linked to brain atrophy and an increased risk of Alzheimer disease. Objective: To examine the relationship of HCY levels to brain and cognitive measures in a healthy community sample. Design: Cross-sectional study. Setting: Individuals residing in Canberra and Queanbeyan, Australia, who were participating in the longitudinal PATH Through Life Project. Participants: Individuals aged 60 to 64 years selected randomly from the community, 196 men and 189 women. ..