A convenient preparation of dityrosine via Miyaura borylation-Suzuki coupling of iodotyrosine derivatives

Abstract

Dityrosine has been prepared from 3-iodo-L-tyrosine derivatives by sequential Miyaura borylation and Suzuki coupling reactions. A tandem borylation-coupling protocol results in improved yields of the dityrosine derivatives. Suitable protecting group strategies are employed to allow for global deprotection as the final step. © 2003 Elsevier Science Ltd. All rights reserved.