Journal article

Double-blind, randomized trial of long-chain polyunsaturated fatty acid supplementation in formula fed to preterm infants

MS Fewtrell, R Morley, RA Abbott, A Singhal, EB Isaacs, T Stephenson, U MacFadyen, A Lucas

PEDIATRICS | AMER ACAD PEDIATRICS | Published : 2002

Abstract

OBJECTIVE: We tested the hypothesis that balanced addition of long-chain polyunsaturated fatty acid (LCPUFA) to preterm formula during the first weeks of life would confer long-term neurodevelopmental advantage in a double-blind, randomized, controlled trial of preterm formula with and without preformed LCPUFA. METHODS: The participants were 195 formula-fed preterm infants (birth weight <1750 g, gestation <37 weeks) from 2 UK neonatal units and 88 breast milk-fed infants. Main outcome measures were Bayley Mental Developmental Index (MDI) and Psychomotor Developmental Index (PDI) at 18 months and Knobloch, Passamanick and Sherrard's Developmental Screening Inventory at 9 months' corrected age..

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