Journal article

Expression and cellular localisation of chloride intracellular channel 3 in human placenta and fetal membranes

TT Money, RG King, MH Wong, JL Stevenson, B Kalionis, JJHM Erwich, MA Huisman, A Timmer, U Hiden, G Desoye, NM Gude

PLACENTA | W B SAUNDERS CO LTD | Published : 2007


Chloride channels regulate the movement of a major cellular anion and are involved in fundamental processes that are critical for cell viability. Regulation of intracellular chloride is achieved by multiple classes of channel proteins. One class of putative channels are the chloride intracellular channel (CLIC) family. Evidence suggests that several CLICs are expressed in human placenta, although their roles in this tissue are not certain. Northern blot analysis has shown that CLIC3 is highly expressed in placenta relative to other human tissues; however, its cellular distribution is not known. This study used microarray expression profiling to clarify which CLICs are expressed in human plac..

View full abstract