Journal article

Evaluation of cancer therapy using diffusion magnetic resonance imaging

BD Ross, BA Moffat, TS Lawrence, SK Mukherji, SS Gebarski, DJ Quint, TD Johnson, L Junck, PL Robertson, KM Muraszko, Q Dong, CR Meyer, PH Bland, P McConville, HR Geng, A Rehemtulla, TL Chenevert

MOLECULAR CANCER THERAPEUTICS | AMER ASSOC CANCER RESEARCH | Published : 2003

Abstract

Assessment of the effectiveness of cancer therapy traditionally relies on comparison of tumor images acquired before and after therapeutic intervention by inspection of gross anatomical images to evaluate changes in tumor size. The potential for imaging to provide additional insights related to the therapeutic impact would be enhanced if a specific parameter or combination of parameters could be identified that reflect tissue changes at the cellular or physiological level. This information could also provide a more sensitive and earlier indicator of treatment response in an individual animal or patient. Diffusion magnetic resonance imaging can detect relatively small changes in tissue struct..

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University of Melbourne Researchers