Journal article

Acute management of dengue shock syndrome: A randomized double-blind comparison of 4 intravenous fluid regimens in the first hour

NT Nhan, CXT Phuong, R Kneen, B Wills, N Van My, NTQ Phuong, C Van Thien, NTT Nga, JA Simpson, T Solomon, NJ White, J Farrar

CLINICAL INFECTIOUS DISEASES | OXFORD UNIV PRESS INC | Published : 2001

Abstract

Dengue hemorrhagic fever is an important cause of morbidity among Asian children, and the more severe dengue shock syndrome (DSS) causes a significant number of childhood deaths. DSS is characterized by a massive increase in systemic capillary permeability with consequent hypovolemia. Fluid resuscitation is critical, but as yet there have been no large trials to determine the optimal fluid regimen. We undertook a randomized blinded comparison of 4 fluids (dextran, gelatin, lactated Ringer's, and "normal" saline) for initial resuscitation of 230 Vietnamese children with DSS. All the children survived, and there was no clear advantage to using any of the 4 fluids, but the longest recovery time..

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