Journal article

A combined spectroscopic and functional MRI investigation of the dorsal anterior cingulate region in opiate addiction

M Yucel, DI Lubman, BJ Harrison, A Fornito, NB Allen, RM Wellard, K Roffel, K Clarke, SJ Wood, SD Forman, C Pantelis

MOLECULAR PSYCHIATRY | NATURE PUBLISHING GROUP | Published : 2007

Abstract

Converging neuropsychological and functional neuroimaging evidence indicates that the dorsal anterior cingulate cortex (dACC) is dysfunctional in drug-addicted populations. Few studies, however, have investigated the biochemical and physiological properties of the dACC in such populations. We used proton magnetic resonance spectroscopy ((1)H-MRS) together with functional magnetic resonance imaging (fMRI) to probe dACC biochemistry and physiological activity during performance of a behavioural control task in 24 opiate-dependent individuals (maintained on a stable dose of methadone or buprenorphine at the time of study) and 24 age, gender, intelligence and performance-matched healthy subjects..

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