Journal article

Neuroimaging and emerging psychotic disorders: The Melbourne ultra-high risk studies

C Pantelis, D Velakoulis, SJ Wood, M Yuecel, AR Yung, LJ Phillips, D-Q Sun, PD Mcgorry

INTERNATIONAL REVIEW OF PSYCHIATRY | TAYLOR & FRANCIS LTD | Published : 2007

Abstract

Although the underlying neurobiology of emerging psychotic disorders is not well understood, evidence from structural imaging and other studies support the notion that schizophrenia arises as a consequence of both an 'early neurodevelopmental' disturbance, as well as 'late neurodevelopmental' changes occurring during the initial stages of a psychotic illness, including around the time of transition to illness. In line with this, our longitudinal MRI findings in individuals at ultra-high risk for developing a psychotic illness show that there are excessive neuroanatomical changes in those who convert to psychosis. These aberrant changes are observed most prominently in medial temporal and pre..

View full abstract