Journal article

Acute serotonin and dopamine depletion improves attentional control: Findings from the Stroop task

Kirsty E Scholes, Ben J Harrison, Barry V O'Neill, Sumie Leung, Rodney J Croft, Andrew Pipingas, K Luan Phan, Pradeep J Nathan



Schizophrenia is associated with impairments of attentional control on classic experimental paradigms such as the Stroop task. However, at a basic level the neurochemical mechanisms that may be responsible for such impairments are poorly understood. In this study, we sought to investigate the influence of brain monoamine function on Stroop task performance in healthy participants using the established methods of acute dietary serotonin, dopamine, and combined monoamine depletion. The study was a double-blind placebo controlled design in which 12 healthy male participants completed the Stroop task under four acute treatment conditions: (a) balanced/placebo control, (b) acute tryptophan deplet..

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University of Melbourne Researchers