Journal article

Safety of the insect repellent N, N-diethyl-M-toluamide (DEET) in pregnancy

R McGready, KA Hamilton, JA Simpson, TI Cho, C Luxemburger, R Edwards, S Looareesuwan, NJ White, F Nosten, SW Lindsay

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE | AMER SOC TROP MED & HYGIENE | Published : 2001

Abstract

The safety of daily application of N, N-diethyl-m-toluamide (DEET) (1.7 g of DEET/day) in the second and third trimesters of pregnancy was assessed as part of a double-blind, randomized, therapeutic trial of insect repellents for the prevention of malaria in pregnancy (n = 897). No adverse neurologic, gastrointestinal, or dermatologic effects were observed for women who applied a median total dose of 214.2 g of DEET per pregnancy (range = 0-345.1 g). DEET crossed the placenta and was detected in 8% (95% confidence interval = 2.6-18.2) of cord blood samples from a randomly selected subgroup of DEET users (n = 50). No adverse effects on survival, growth, or development at birth, or at one year..

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