Journal article

The neuropsychiatry of adrenomyeloneuropathy

Mark A Walterfang, John O'Donovan, Michael C Fahey, Dennis Velakoulis

CNS SPECTRUMS | M B L COMMUNICATIONS, INC | Published : 2007

Abstract

BACKGROUND: While the adult form of adrenoleukodystrophy (ALD) has been associated with an elevated rate of affective disturbance, the myeloneuropathic form of the disease known as adrenomyeloneuropathy (AMN) has been associated with only occasional cases of major mental illness. Given that cerebral involvement occurs in up to half of AMN sufferers, we hypothesized that rates of mental illness may match those with adult ALD. OBJECTIVE: To describe the psychiatric, cognitive, and disability variables in a sample of Australian AMN sufferers. METHODS: Ten genetically confirmed AMN sufferers underwent diagnostic psychiatric interview (Structured Clinical Interview for Diagnostic and Statistical ..

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