Hippocampal 5-hydroxytryptamine receptors: Abnormalities in postmortem brain from schizophrenic subjects

Abstract

There is strong evidence that hippocampal 5-hydroxytryptamine (5-HT) systems are affected in schizophrenia and hence we have studied a number of markers of the 5-HT system in hippocampi from subjects with schizophrenia. Using in situ radioligand binding with autoradiography we measured [ 3H]proplyamino-8-hydroxy-1,2,3,4-tetrahydronapthalene, [ 3H]ketanserin and [3H]sumatriptan binding in hippocampi from 20 schizophrenic and 20 control subjects. There were significant decreases in the density of [3H]ketanserin binding to the 5-HT2A receptor (5-HT2AR) in the Cornu Ammonis (CA) 3 (p=0.006), CA 1 (stratum radiatum p=0.02; pyramidal layer p=0.0008) and subiculum (pyramidal layer p=0.0004), as wel..