Measurement of dopamine D2-like receptors in postmortem CNS and pituitary: Differential regional changes in schizophrenia

Abstract

In situ radioligand binding with autoradiography and anti-human dopamine D2 receptor antibodies with Western blots have been used to measure the density of dopamine D2-like receptors in the caudate-putamen and pituitary from schizophrenic subjects who did or did not have residual antipsychotic drugs in their tissue at death. There was a significant decrease in the Ki for haloperidol displaceable [125I]iodosulpride binding in the pituitary (p < 0.01) and caudate-putamen (p < 0.05) from subjects with schizophrenia with residual drugs in their tissue. There was a significant decrease in the density of [125I]iodosulpride in the pituitary (p < 0.001) and a strong trend to a decrease in binding in..