Journal article

The exercise-induced expression of BDNF within the hippocampus varies across life-span

PA Adlard, VM Perreau, CW Cotman

NEUROBIOLOGY OF AGING | ELSEVIER SCIENCE INC | Published : 2005

Abstract

Voluntary exercise increases hippocampal brain-derived neurotrophic factor (BDNF) expression in young animals. In this investigation we examined the induction of BDNF protein in the hippocampus of young (2 months), late middle-aged (15 months) and old (24 months) animals over 4 weeks of exercise. Average running distances decreased with age, with the old animals also maintaining a constant level of activity over time, whereas the other groups tended to increase their average running distance. All animals demonstrated a biphasic profile of BDNF protein induction, with a significant (P<0.05) increase after 1 week of exercise followed by a decrease to near sedentary levels at 2 weeks. After thi..

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