Journal article

Cell-mediated protection in influenza infection

PG Thomas, R Keating, DJ Hulse-Post, PC Doherty

Emerging Infectious Diseases | CENTERS DISEASE CONTROL & PREVENTION | Published : 2006


Current vaccine strategies against influenza focus on generating robust antibody responses. Because of the high degree of antigenic drift among circulating influenza strains over the course of a year, vaccine strains must be reformulated specifically for each influenza season. The time delay from isolating the pandemic strain to large-scale vaccine production would be detrimental in a pandemic situation. A vaccine approach based on cell-mediated immunity that avoids some of these drawbacks is discussed here. Specifically, cell-mediated responses typically focus on peptides from internal influenza proteins, which are far less susceptible to antigenic variation. We review the literature on the..

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University of Melbourne Researchers