Journal article

Retinal microvascular abnormalities and incident stroke: the atherosclerosis risk in communities study

TY Wong, R Klein, DJ Couper, LS Cooper, E Shahar, LD Hubbard, MR Wofford, AR Sharrett

LANCET | ELSEVIER SCIENCE INC | Published : 2001

Abstract

BACKGROUND: Retinal microvascular abnormalities reflect damage from hypertension and other vascular processes. We examined the relation of such abnormalities to incident stroke. METHODS: A cohort of 10358 men and women (aged 51 to 72 years) living in four US communities underwent retinal photography and standard grading for retinal microvascular abnormalities. The calibres of all retinal arterioles and venules were measured after digital conversion of the photographs, and a summary arteriole-to-venule ratio (AVR) was calculated as an index of arteriolar narrowing (smaller AVR indicates greater narrowing). Cases of incident stroke admitted to hospital were identified and validated by case rec..

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