Journal article

Therapeutic treatments for Alzheimer's disease based on metal bioavailability

Peter J Crouch, Kevin J Barnham, Ashley I Bush, Anthony R White

DRUG NEWS & PERSPECTIVES | PROUS SCIENCE, SAU-THOMSON REUTERS | Published : 2006

Abstract

The amyloid beta peptide (Abeta) has been widely implicated as a significant causative agent in Alzheimer's disease, although the common mechanistic links between Abeta and other critical elements of Alzheimer's disease, such as advancing age and oxidative stress, are still poorly understood. Here we review data indicating that biometal dyshomeostasis plays a role in these aspects of Alzheimer's disease. Although strong evidence has been published demonstrating a role for iron and zinc in Alzheimer's disease, we have here limited our discussion to data on the role of copper. We also describe how the development of therapeutic agents designed to modulate metal bioavailability has provided pro..

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