Journal article

Structural organization and expression of human MTUS1, a candidate 8p22 tumor suppressor gene encoding a family of angiotensin II AT2 receptor-interacting proteins, ATIP

M Di Benedetto, I Bieche, F Deshayes, S Vacher, S Nouet, V Collura, I Seitz, S Louis, P Pineau, D Amsellem-Ouazana, PO Couraud, AD Strosberg, D Stoppa-Lyonnet, R Lidereau, C Nahmias

GENE | ELSEVIER | Published : 2006

Abstract

The Mitochondrial Tumor suppressor 1 (MTUS1) gene is a newly identified candidate tumor suppressor gene at chromosomal position 8p22. We report here that MTUS1 encodes a family of proteins whose leader member (ATIP1) was previously isolated in our laboratory as a novel interacting partner of the angiotensin II AT2 receptor involved in growth inhibition (Nouet, JBC 279: 28989-97, 2004). The MTUS1 gene contains 17 coding exons distributed over 112 kb of genomic DNA. Alternative exon usage generates three major transcripts (ATIP1, ATIP3 and ATIP4), each showing different tissue distribution. ATIP polypeptides are identical in their carboxy-terminal region carrying four coiled-coil domains. In t..

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University of Melbourne Researchers