Journal article

Clinical efficacy of moxifloxacin in the treatment of bacterial keratitis - A Randomized clinical trial

Marios Constantinou, Mark Daniell, Grant R Snibson, Hien T Vu, Hugh R Taylor

OPHTHALMOLOGY | ELSEVIER SCIENCE INC | Published : 2007

Abstract

PURPOSE: To determine the clinical efficacy and safety of moxifloxacin (1.0%) in patients with bacterial keratitis compared with patients treated with ofloxacin (0.3%) or fortified tobramycin (1.33%)/cephazolin (5%). DESIGN: Prospective randomized trial. PARTICIPANTS: A total of 229 patients diagnosed with bacterial keratitis were enrolled in the study; 78 patients were randomized to the fortified tobramycin/cephazolin group, 77 patients to the moxifloxacin group, and 74 patients to the ofloxacin group. A total of 225 patients were evaluable for safety and 198 patients were included in the efficacy analysis. INTERVENTION: After corneal specimens were obtained, the assigned study medication w..

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