Journal article

Hyperbaric oxygen therapy for severe acute pancreatitis

Christopher Christophi, Ian Millar, Mehrdad Nikfarjam, Vijayaragavan Muralidharan, Caterina Malcontenti-Wilson

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY | WILEY-BLACKWELL | Published : 2007

Abstract

Despite improvements in the supportive management of severe acute pancreatitis over the last decade, the morbidity and mortality rate remains high. The main feature of this condition is pancreatic necrosis leading to sepsis, with both localized and systemic inflammatory response syndromes. Early pathophysiological changes of the pancreas include alterations in microcirculation, ischemia reperfusion injury, and leukocyte and cytokine activation. The efficacy of hyperbaric oxygen (HBO) therapy in improving these pathophysiological disturbances is documented for various conditions. However, its effect in the treatment of severe acute pancreatitis is undetermined. This report documents the case ..

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