Journal article

Brain structural correlates of depressive comorbidity in obsessive-compulsive disorder

Narcis Cardoner, Carles Soriano-Mas, Jesus Pujol, Pino Alonso, Ben J Harrison, Joan Deus, Rosa Hernandez-Ribas, Jose M Menchon, Julio Vallejo

NEUROIMAGE | ACADEMIC PRESS INC ELSEVIER SCIENCE | Published : 2007

Abstract

The high comorbidity of obsessive-compulsive disorder (OCD) with major depressive disorder (MDD) suggests common neurobiological substrates. We assessed the contribution of lifetime MDD to brain structural alterations in OCD using magnetic resonance imaging. OCD patients with (n=33) or without (n=39) lifetime MDD, and 72 control subjects were assessed. Comparative region of interest (ROI) analyses assessed the contribution of lifetime MDD to gray matter volume alterations in OCD patients. Interregional correlations of gray matter volume were also examined and voxelwise analyses were performed to identify alterations in other brain regions. OCD patients with lifetime MDD showed a larger reduc..

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University of Melbourne Researchers