Are neuropsychological impairments in children with early-treated phenylketonuria (PKU) related to white matter abnormalities or elevated phenylalanine levels?
Peter J Anderson, Stephen J Wood, Dorothy E Francis, Lee Coleman, Vicki Anderson, Avihu Boneh
DEVELOPMENTAL NEUROPSYCHOLOGY | ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD | Published : 2007
This study aimed to enhance our understanding of neuropsychological functioning in children with early-treated phenylketonuria (PKU) and assess the relative impact of white matter abnormalities (WMA) and neurotransmitter deficiencies on cognitive functions in this population. The study consisted of 33 children with early-treated PKU and 34 healthy control children aged between 7 to 18 years. All children had a neuropsychological evaluation that included measures of general intelligence, attention, processing speed, memory and learning, executive function, and academic achievement. Children in the PKU group also had a magnetic resonance (MR) brain scan. When compared with the control group, t..View full abstract