Journal article

Dppa2 and Dppa4 are closely linked SAP motif genes restricted to pluripotent cells and the germ line

Joanna Maldonado-Saldivia, Jocelyn Van den Bergen, Margarita Krouskos, Mike Gilchrist, Caroline Lee, Rui Li li, Andrew H Sinclair, M Azim Surani, Patrick S Western

STEM CELLS | ALPHAMED PRESS | Published : 2007


Despite the enormous medical potential of ESCs, the molecular mechanisms conferring the ability to differentiate into all cell types of the embryo remain elusive. We used an in silico approach to identify genes expressed exclusively in mouse preimplantation embryos and pluripotent cell lines. Two of these genes were developmental pluripotency-associated gene 2 (Dppa2) and Dppa4, which we show are closely linked genes encoding putative nuclear SAP domain proteins expressed in human and mouse pluripotent stem cells and germ cell tumor-derived embryonal carcinoma cells. In the mouse, these genes are transcribed in germinal vesicle-stage oocytes and throughout the cleavage stages of embryogenesi..

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