Journal article

Oesophagostomum dentatum - Potential as a model for genomic studies of strongylid nematodes, with biotechnological prospects

Robin B Gasser, Pauline Cottee, Alasdair J Nisbet, Baerbel Ruttkowski, Shoba Ranganathan, Anja Joachim

BIOTECHNOLOGY ADVANCES | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2007

Abstract

There are substantial gaps in the knowledge of the molecular processes of development and reproduction in parasitic nematodes, despite the fact that understanding such processes could lead to novel ways of treating and controlling parasitic diseases, through blocking or disrupting key biological pathways. Biotechnological advances through large-scale sequencing projects, approaches for the analysis of differential gene and protein expression and functional genomics (e.g., double-stranded RNA interference) now provide opportunities to investigate the molecular basis of developmental processes in some parasitic nematodes. The porcine nodule worm, Oesophagostomum dentatum (order Strongylida), m..

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