Journal article

Vimentin and epithelial-mesenchymal transition in human breast cancer - Observations in vitro and in vivo

Maria I Kokkinos, Razan Wafai, Meng Kang Wong, Donald F Newgreen, Erik W Thompson, Mark Waltham

CELLS TISSUES ORGANS | KARGER | Published : 2007

Abstract

Breast cancer is a highly prevalent disease among women worldwide. While the expression of certain proteins within these tumours is used for prognosis and selection of therapies, there is a continuing need for additional markers to be identified. A considerable amount of current literature, based predominantly on cell culture systems, suggests that a major mechanism responsible for the progression of breast cancer is due to tumour cells losing their epithelial features and gaining mesenchymal properties. These events are proposed to be very similar to the epithelial-mesenchymal transition (EMT) process that has been well characterised in embryonic development. For the developmental and putat..

View full abstract