Journal article

Visual assessment versus quantitative assessment of C-11-PIB PET and F-18-FDG PET for detection of Alzheimer's disease

Steven Ng, Victor L Villemagne, Sam Berlangieri, Sze-Ting Lee, Martin Cherk, Sylvia J Gong, Uwe Ackermann, Tim Saunder, Henri Tochon-Danguy, Gareth Jones, Clare Smith, Graeme O'Keefe, Colin L Masters, Christopher C Rowe

JOURNAL OF NUCLEAR MEDICINE | SOC NUCLEAR MEDICINE INC | Published : 2007

Abstract

UNLABELLED: Amyloid-beta (Abeta) imaging with N-methyl-(11)C-2-(4'-methylamino-phenyl)-6-hydroxy-benzothiazole ((11)C-6-OH-BTA-1; also known as (11)C-PIB) shows a robust increase in cortical binding in Alzheimer's disease (AD). The aim of this study was to explore the clinical potential of Abeta imaging for the diagnosis of AD by comparison of the accuracy of visual reading of (11)C-PIB images with quantitative analysis and (18)F-FDG. METHODS: Fifteen AD patients (age, 71.1 +/- 11.3 y [mean +/- SD]; mini-mental state examination [MMSE], 18.9 +/- 9.3 [mean +/- SD]) and 25 healthy control (HC) subjects (age, 71.9 +/- 6.82 y; MMSE >or= 28) underwent 90-min dynamic (11)C-PIB PET and 20-min stati..

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