Journal article

Early postnatal stress confers enduring vulnerability to limbic epileptogenesis

Michael Salzberg, Gaurav Kumar, Laureen Supit, Nigel C Jones, Margaret J Morris, Sandra Rees, Terence J O'Brien

Epilepsia | WILEY | Published : 2007


PURPOSE: Early life stress has enduring behavioral and neuroendocrine effects, particularly in hippocampus and amygdala. This may be relevant to mesial temporal lobe epilepsy (MTLE) that arises from these structures. In rats, we tested the hypothesis that early postnatal stress, in the form of maternal separation (MS), creates vulnerability to limbic epileptogenesis in adult life. METHODS: On postnatal days 2-14, we exposed male and female nonepileptic rats to either MS for 180 min/day, or early handling (EH) and brief separation (15 min/day). At 7 weeks of age, rats of both genders exposed to MS displayed significantly increased anxiety, as evidenced by reduced time spent in the open arms o..

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