Journal article

Contraindications to metformin therapy in patients with Type 2 diabetes - a population-based study of adherence to prescribing guidelines

AM Emslie-Smith, DIR Boyle, JMM Evans, F Sullivan, AD Morris

DIABETIC MEDICINE | BLACKWELL SCIENCE LTD | Published : 2001

Abstract

AIMS: To define the number of people in Tayside, Scotland (population 349 303) with Type 2 diabetes who use metformin, the incidence of contraindications to its continued use in these people and the proportion that discontinued metformin treatment following the development of a contraindication. METHODS: Retrospective cohort study of the incidence of contraindications to metformin in all patients with Type 2 diabetes using metformin from January 1993 to June 1995. The contraindications of acute myocardial infarction, cardiac failure, renal impairment and chronic liver disease were identified by: the regional diabetes information system, biochemistry database and hospital admissions database ..

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University of Melbourne Researchers