Journal article

Assessment of the protective effect of pneumococcal vaccination in preventing meningitis after cochlear implantation

Benjamin PC Wei, Roy M Robins-Browne, Robert K Shepherd, Kristy Azzopardi, Graeme M clark, Stephen J O'Leary

ARCHIVES OF OTOLARYNGOLOGY-HEAD & NECK SURGERY | AMER MEDICAL ASSOC | Published : 2007

Abstract

OBJECTIVES: To examine if a 23-valent pneumococcal capsular polysaccharide vaccine (PPV23) reduces the risk of meningitis in healthy rats after cochlear implantation. DESIGN: Interventional animal study. INTERVENTIONS: Thirty-six rats (18 immunized and 18 unimmunized) received cochlear implantations and were then infected with Streptococcus pneumoniae via 3 different routes (hematogenous, middle ear, and inner ear) in numbers sufficient to induce meningitis. RESULTS: The rats with implants that received PPV23 were protected from meningitis when the bacteria were delivered via the hematogenous and middle-ear routes (Fisher exact test P<.05). However, the protective effect of the vaccine in th..

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