Journal article

Specificity on a knife-edge: the alpha beta T cell receptor

Craig S Clements, Michelle A Dunstone, Whitney A Macdonald, James McCluskey, Jamie Rossjohn

CURRENT OPINION IN STRUCTURAL BIOLOGY | CURRENT BIOLOGY LTD | Published : 2006

Abstract

The interaction between the alphabeta T cell receptor (TCR) and the peptide bound to the major histocompatibility complex class I molecule (pMHC-I) constitutes a central interaction in adaptive immunity. How these receptors interact with such low affinity while maintaining exquisite specificity for peptide antigen and host MHC (MHC-I restriction) remains a challenge to be explained by structural immunologists. Moreover, how this extracellular interaction is transmitted as an intracellular signal via the CD3 complex remains unresolved. Nevertheless, several structures of TCRs, non-liganded and ligated to a defined pMHC-I, combined with detailed biophysical analyses, have provided insight of t..

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University of Melbourne Researchers