Measurement of aldosterone in feline, canine and human urine

Abstract

Background: Systemic hypertension is an important problem in older cats associated with kidney disease and hypokalaemia, suggesting that excessive activity of the renin-angiotensin-aldosterone system might contribute to the hypertensive state. Fluctuations in plasma renin activity and plasma aldosterone concentrations complicate the interpretation of these assays. Objectives: The aim of this study was to determine whether measurement of urinary aldosterone excretion in cats aided the investigation of hypertension. Methods: Urine concentrations of free (ethyl acetate extract) and 18-glucuronidated aldosterone (acid hydrolysis before extraction) were measured by radioimmunoassay in normal, nor..