Journal article

Protection of xenografts by a combination of immunoisolation and a single dose of anti-CD4 antibody

AW McKenzie, HM Georgiou, YF Zhan, JL Brady, AM Lew

CELL TRANSPLANTATION | COGNIZANT COMMUNICATION CORP | Published : 2001

Abstract

Immunoisolation is the separation of transplanted cells from cells of the immune system using a semipermeable membrane. Using one such immunoisolation capsule-the TheraCyte device-we have assessed the survival of encapsulated xenogeneic tissue in vivo as well as the contribution of CD4+ve T cells to encapsulated xenograft rejection. The foreign body reaction to the TheraCyte capsule in vivo was assessed by transplanting empty capsules into normal mice. These capsules elicit a foreign body response by the host animal. Encapsulated CHO, NIT-1, and PK-15 cells were placed in culture and in immunodeficient mice to investigate their growth characteristics in the TheraCyte device. These cell lines..

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