Chronic ferritin expression within murine dopaminergic midbrain neurons results in a progressive age-related neurodegeneration
Deepinder Kaur, Subrarnanian Rajagopalan, Shankar Chinta, Jyothi Kumar, Donato Di Monte, Robert A Cherny, Julie K Andersen
BRAIN RESEARCH | ELSEVIER | Published : 2007
Ferritin elevation has been reported by some laboratories to occur within the substantia nigra (SN), the area of the brain affected in Parkinson's disease (PD), but whether such an increase could be causatively involved in neurodegeneration associated with the disorder is unknown. Here, we report that chronic ferritin elevation in midbrain dopamine-containing neurons results in a progressive age-related neurodegeneration of these cells. This provides strong evidence that chronic ferritin overload could be directly involved in age-related neurodegeneration such as occurs in Parkinson's and other related diseases.
Awarded by NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE
Awarded by NINDS NIH HHS